collagen type iv การใช้

• LOXL2 can also crosslink collagen type IV and hence influence the sprouting of new blood vessels.
• In a normal wall of arteries, collagen type IV acts to inhibit smooth muscle cell proliferation.
• It has been found that sponges do have a gene sequence coding for collagen type IV which is a diagnostic feature of the basal lamina
• Non-collagenous domain basement membrane collagen type IV is autoantigen ( target antigen ) of autoantibodies in the autoimmune disease Goodpasture's syndrome.
• In humans, a novel mutation of the COL4A1 gene coding for collagen type IV was found to be associated with autosomal dominant congenital cataract in a Chinese family.
• This subfamily consists of PCTP, collagen type IV alpha-3-binding protein or StarD11, all of which bind phosphatidylcholine except for StarD11 which prefers ceramide.
• Luxol fast blue staining identifies myelin sheathing of some fibers, and lesional cells react immunohistochemically for S-100 protein, collagen type IV, vimentin, NSE, and neural filaments.
• Another example of type II hypersensitivity reaction is Goodpasture's syndrome where the basement membrane ( containing collagen type IV ) in the lung and kidney is attacked by one's own antibodies.
• This report of a new mutation in the COL4A1 gene is the first report of a non-syndromic autosomal dominant congenital cataract that highlights an important role for collagen type IV in the physiological and optical properties of the lens.
• Accordingly, it was demonstrated that protein expression of collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGF? mediated stimulation of mRNA . Altogether, it was concluded that the pathogenesis of coronary artery disease may be regulated by COL4A1 and COL4A2 genes.